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| Lopes,Danielly Bandeira; Nascimento,Guilherme Nobre Lima do; Carvalho,Adryano Augustto Valladão de; Souza Neto,Advaldo Carlos de; Lima,Natácia Evangelista de; Aversi-Ferreira,Tales Alexandre. |
| The verification of the acute effects of ethanol on the midbrain, which neurons are mainly formed in E14, will ratify if the acute effects of ethanol are associated, in terms of prevalence, to the date of birth of neurons in certain regions of the brain. The aim of this study was to determine the effects of acute exposure to ethanol on the neuronal density of the midbrain and to associate these results with acute effects of ethanol in other regions of the brain under the same conditions. The rats were treated with intraperitoneal ethanol during one day (E12) and 1h after the last ethanol injection was applied to BrdU. The animals were sacrificed; the brains were removed and sectioned. The sections were treated with DAB for the BrdU revelation, the slides... |
| Tipo: Journal article |
Palavras-chave: Ethanol; Brain; Midbrain; Neuronal migration; Fetal Alcohol Syndrome. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000300009 |
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| CAVALCANTE,LENY A.; GARCIA-ABREU,JOSÉ; MOURA NETO,VIVALDO; SILVA,LUIZ CLAUDIO; WEISSMÜLLER,GILBERTO. |
| Bilaterally symmetric organisms need to exchange information between the left and right sides of their bodies to integrate sensory input and to coordinate motor control. Thus, an important choice point for developing axons is the Central Nervous System (CNS) midline. Crossing of this choice point is influenced by highly conserved, soluble or membrane-bound molecules such as the L1 subfamily, laminin, netrins, slits, semaphorins, Eph-receptors and ephrins, etc. Furthermore, there is much circumstantial evidence for a role of proteoglycans (PGs) or their glycosaminoglycan (GAG) moieties on axonal growth and guidance, most of which was derived from simplified models. A model of intermediate complexity is that of cocultures of young neurons and astroglial... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Astrocytes; Axon growth; Extracellular matrix; Heparan sulfate; Midline; Midbrain. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000400010 |
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| Cavalcante,L.A.; Garcia-Abreu,J.; Mendes,F.A.; Moura Neto,V.; Silva,L.C.F.; Onofre,G.; Weissmüller,G.; Carvalho,S.L.. |
| Proteoglycans are abundant in the developing brain and there is much circumstantial evidence for their roles in directional neuronal movements such as cell body migration and axonal growth. We have developed an in vitro model of astrocyte cultures of the lateral and medial sectors of the embryonic mouse midbrain, that differ in their ability to support neuritic growth of young midbrain neurons, and we have searched for the role of interactive proteins and proteoglycans in this model. Neurite production in co-cultures reveals that, irrespective of the previous location of neurons in the midbrain, medial astrocytes exert an inhibitory or nonpermissive effect on neuritic growth that is correlated to a higher content of both heparan and chondroitin sulfates... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Astrocytes; Axonal growth; Chondroitin sulfate; Heparan sulfate; Midline; Midbrain. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800005 |
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